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KMID : 0921620120420020169
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Journal of Bacteriology and Virology
2012 Volume.42 No. 2 p.169 ~ p.171
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Caspase-11, the Main Executioner in Non-canonical Inflammasome
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Manzoor Zahid
Koh Young-Sang
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Abstract
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Murine caspase-11 is orthologus to human caspase-4 and caspase-5, and is required for the response to cholera toxin B and infection with Escherichia coli, Citrobacter rodentium or Vibrio cholerae. Caspase-11 rather than caspase-1 is the main offender involved in sepsis. Hence, caspase-11 plays an essential pro-inflammatory role in innate immune response to bacterial infections
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KEYWORD
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Caspase-11, Caspase-1, Sepsis, Inflammasome
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